By E. G. Snyderwine (auth.), Prof. Dr. med. Hans-Jörg Senn, Richard D. Gelber Ph.D, Prof. Dr. med. Aron Goldhirsch, Priv.-Doz. Dr. med. Beat Thürlimann (eds.)
This quantity presents an updated survey of present laboratory and, in most cases, scientific learn at the diagnostic and treatment plans in basic breast melanoma. The chapters derive from the invited specialist lectures offered on the sixth overseas convention on fundamental Breast melanoma held in St. Gallen, Switzerland, in February 1998. the global breast melanoma group has been eagerly watching for this quantity and its consensus platform and suggestions. there isn't any replacement to this assembly and publication within the box of adjuvant treatment of fundamental breast cancer.
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Additional resources for Adjuvant Therapy of Primary Breast Cancer VI
1996; Bonnier et al. 1995). Paradoxically, however, it has been suggested that there are also fewer ER+ tumors in this setting (Harding et al. 1996; Bonnier et al. 1995). Overall, the suggestion is that in women who develop breast cancer while on ERTIHRT, mortality may be lower than in women who develop breast cancer while not receiving ERTI HRT. Norlock et al. (1998) have recently shown interesting data suggesting that women developing breast cancer while receiving ERT/HRT have the same proportion of ER+ tumors as do those not receiving ERT/HRT, but that in women with ER+ tumors which developed while they were receiving ERTI HRT, progesterone receptor (PgR) levels are higher and S-phase levels are also higher.
Along this line of research, studies on tamoxifen and fenretinide have lately provided encouraging results. Moreover, the combination of these two agents already demonstrated to be effective in preventing experimental breast cancer - looks quite promising, and a clinical trial is currently underway. In addition, new selective estrogen receptor modulators (SERMs) with potentially improved safety proftles may become available. Importantly, the recent demonstration that estrogen receptor overexpression in normal breast tissue may increase breast cancer risk (Khan et al.
Cancer Inst 88:643-649 Lobo BA (1991) Effects of hormonal replacement on lipids and lipoproteins in postmenopausal women. J Clin Endocrinol Metab 73:925-931 Lufkin EG, Wahner HW, O'Fallon WM, Hodgson SF, Kotowicz MA, Lane AW, Judd HL, Caplan RH, Riggs BL (1992) Treatment of postmenopausal osteoporosis with transdermal estrogen. Ann Intern Med 117:1-9 Nabulsi MB, Folsom AR, White A, Patsch W, Heiss G, Wu KK, Szklo M (1993) Association of hormone-replacement therapy with various cardiovascular risk factors in postmenopausal women.