By Dr. med. Sabine Enenkel, Professor Dr. Wolfgang Stille (auth.)
International textbooks on infectious illnesses and antibacterial chemotherapy are typically written for readers in North the USA and Europe. in lots of methods, they don't seem to be acceptable for the prob lems encountered in constructing nations. This publication, by contrast, intends to outline the foundations of antibacterial chemotherapy practised below stipulations of restricted assets. it's intended for everybody con cerned with using antibiotics in constructing international locations, includ ing medical professionals, clinical assistants, pharmacists, officers in healthiness mio isteries, and scientific scholars. during the ebook, remedy concepts are made for 1 antibiotics from the WHO checklist of crucial medications. for instance, em phasis has accordingly been positioned upon chloramphenicol as a strong, unexpensive and greatly on hand oral agent compatible for the deal with ment of serious bacterial infections like septicemia and meningitis. So-called "international chemotherapy" with modem cephalospor ins and acylaminopenicillins has been defined for comparability. because it is the purpose of the publication to base therapy recommenda tions on facts from constructing nations, many info at the etiology of universal bacterial infections in constructing international locations have additionally been integrated. lots of the facts are from African, English-speak ing constructing nations, yet references were made to the lit erature on South East Asia, India or Papua New Guinea, the place applicable. however, pertinent info weren't on hand in each example, in order that numerous statements and proposals needed to be made as "best guess". The authors are conscious of those imperfections and should welcome reviews from the readers.
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Additional resources for Antibiotics in the Tropics: Antibacterial Therapy with Limited Resources
G. staphylococci, Hemophilus, enterobacteria). Pharmacokinetics. Oral and parenteral administration, half-life about 1 h, renal excretion of amoxicillin higher than of clavulanic acid. References 25 Dosage. Orally 1-2 tablets of 375 mg (250 mg amoxicillin and 125 mg clavulanic acid) or 1 tablet of 625 mg (500 mg amoxicillin and 125 mg clavulanic acid) 3 times a day. 2 g (1 g amoxicillin and 200 mg clavulanic acid) both 3 times a day. Main Indications. Infections with amoxicillin-resistant bacteria, the beta-Iactamases of which are inhibited by clavulanic acid.
Dosage. Wide range from 3-15-20 g/day i. v. in two to four divided doses, depending on site and severity of infection. Indications. Severe infections by Pseudomonas, Klebsiella, Proteus, Serratia, usually together with gentamicin. In Europe, often used in complicated urinary tract infection, pelvic inflammatory disease, biliary and abdominal infections, and septicemia. The combination of acylaminopenicillins with cefotaxime is important for the empirical treatment of infections in leukemia. Side Effects.
Burke JP, Levy SB (1985) Summary report on worldwide antibiotic resistance: international task forces on antibiotic use. Rev Infect Dis 7: 560-564 7. B (1981) An outbreak due to multiple drug resistant Serratia marcescens in a children's hospital. Indian J Med Res 74: 196-201 8. Denis FA, Greenwood BD, REy JL, Prince-David M, Mboup S, Lloyd-Evans N, Williams K, Benbachir I, EI Ndaghri N, Hansman D, Omanga V, Krubwa K, Duchassin M, Perrin J (1983) Etude multicentrique des serotypes de pneumocoques en Afrique.