By Anthony W.H. Chan
The liver is a posh organ because of its specific microscopic constitution, difficult metabolic features and susceptibility to a wide selection of insults, manifesting in numerous histological styles. Atlas of Liver Pathology considers either alterations noticeable in clinical liver biopsies in addition to lesional biopsies while the specimen has been taken from a mass. The publication begins by means of reviewing basic constitution and its versions and the optimum ways for the instruction of histological sections for diagnostic liver pathology. the next chapters are devoted to developmental, metabolic, infectious, drug comparable, autoimmune, biliary, vascular and neoplastic issues. sections on liver pathology in being pregnant and transplantation finish the paintings. Macroscopic illustrations are integrated the place applicable. All photos are complemented by means of legends describing the image and offering appropriate similar information.
Authored through nationally and the world over famous pathologists, Atlas of Liver Pathology is a worthwhile source that serves as a brief reference consultant for the prognosis of traditional and weird diseases.
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Additional info for Atlas of Liver Pathology
An oval-shaped eosinophilic intracytoplasmic inclusion is noted. Giant mitochondria, also called megamitochondria, are eosinophilic oval or needle-shaped intracytoplasmic inclusions. They represent enlarged and distended mitochondria with paracrystalline inclusions ultrastructurally. They should be distinguished from other eosinophilic globular intracytoplasmic inclusions, particularly α1-antitrypsin globules. The latter are periodic acid-Schiff (PAS) positive, diastase resistant, and immunoreactive to α1-antitrypsin, whereas the former are not.
38 Glycogen-rich hepatocytes. Almost all hepatocytes in this section are enlarged with cytoplasmic clearing as the result of excessive accumulation of cytoplasmic glycogen. Glycogen-rich hepatocytes may be confused with ballooned hepatocytes in steatohepatitis. The distinction may be complicated further by the fact that glycogenated nuclei and giant mitochondria frequently are found in glycogen-rich hepatocytes. However, diffuse involvement of hepatocytes and minimal steatosis distinguishes glycogen-rich hepatocytes from cells with ballooning degeneration.
Fig. 62 Periductal fibrosis. A bile duct is surrounded by “onionskin” concentric fibrous tissue. Periductal fibrosis is related to activation of peribiliary macrophages and epithelial–mesenchymal transition of cholangiocytes. Periductal fibrosis is a characteristic finding in primary sclerosing cholangitis, secondary sclerosing cholangitis, and ischaemic cholangitis. 5 Fibrosis Fig. 65 Bridging fibrosis (picrosirius red stain). A thick fibrous septum bridges two portal tracts with minimal inflammatory infiltrate and mild ductular reaction.