By Hamed Hatami-Marbini, Mohammad R. K. Mofrad (auth.), Amit Gefen (eds.)
This ebook describes those interesting new advancements, and provides experimental and computational findings that altogether describe the frontier of information in mobile and biomolecular mechanics, and the organic implications, in wellbeing and fitness and illness. The booklet is written for bioengineers with curiosity in mobile mechanics, for biophysicists, biochemists, clinical researchers and all different pros with curiosity in how cells produce and reply to mechanical loads.
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Extra info for Cellular and Biomolecular Mechanics and Mechanobiology
Although no single sensory molecule has been identified specifically for the purpose of mechanotransduction (as has been identified for chemical stimuli, for example), mechanical stimuli in the cellular microenvironment including exogenous forces, physical properties of the ECM, and forces exerted through cell–cell adhesions have a significant effect on cell behavior. It has been shown that cells can sense external forces through a number of mechanisms, including primary cilia, stretch-modulated ion channels, nuclear lamina, the cytoskeleton, and matrix adhesions [53–55].
Cell Motil. Cytoskeleton 40(4), 317–330 (1998) 110. : Demonstration of mechanical connections between integrins, cytoskeletal filaments and nucleoplasm that stabilize nuclear structure. Proc. Natl. Acad. Sci. USA 94, 849–854 (1997) 111. : Band-like stress fiber propagation in a continuum and implications for myosin contractile stresses. Cell. Mol. Bioeng. 2(1), 13–27 (2009) 112. : Cell movement is guided by the rigidity of the substrate. Biophys. J. 79, 144–152 (2000) 113. : Rigidity-driven growth and migration of epithelial cells on microstructured anisotropic substrates.
Stossel, T. , Hartwig, J. , Shapiro, S. : Filamins as integrators of cell mechanics and signaling, Nat. Rev. Mol. Cell Biol. 2, 138–145 (2001) 98. , 498, 72–75 (2001) 99. : Mechanical response of single filamin A (ABP-280) molecules and its role in the actin cytoskeleton. J. Muscle Res. Cell Motil. 23, 525–534 (2002) 100. : Molecular mechanics of the alpha-actinin rod domain: bending, torsional, and extensional behavior. PLoS Comput. Biol. 5(5), e1000389, 1–18 (2009) 101. : Molecular mechanics of filamin rod domain.