By Peter Irving MD MRCP, Corey A. Siegel, David Rampton, Fergus Shanahan
Evidence-based information to respond to greater than 60 debatable scientific questions about inflammatory bowel diseaseClinical Dilemmas in Inflammatory Bowel ailment is a pragmatic instruction manual delivering speedy yet unique solutions to the questions and demanding situations that you're confronted with day-by-day within the medical setting.Each brief bankruptcy addresses a distinct subject and gives evidence-based suggestions on topics starting from optimising present administration via to important administration difficulties and novel remedies. This e-book is acceptable for all doctors all for the care of sufferers with IBD: verified and trainee gastroenterologists, colorectal surgeons, pathologists, radiologists, expert nurses, pharmacists, dieticians and counsellors
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10 Deltenre P, Berson A, Marcellin P, et al. Mesalazine induced chronic hepatitis. Gut 1999; 44: 886 – 8. 11 Rachmilewitz D. Coated mesalazine versus sulphasalazine in the treatment of active ulcerative colitis: a randomised trial. BMJ 1989; 298: 82– 6. 12 Lapidus A, Bangstad M, Astrom M, et al. The prevalence of gallstone disease in a deﬁned cohort of patients with Crohn’s disease. Am J Gastroenterol 1999; 94: 1261– 6. 13 Cucion C, Sonnenberg A. The comorbid occurrence of other diagnoses in patients with ulcerative colitis and Crohn’s disease.
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Hematologic side-effects The 5-ASAs have been associated with a wide range of hematologic side-effects in IBD. Agranulocytosis, red cell aplasia, leukopenia, thrombocytopenia and pancytopenia have all been reported. Antibody-mediated cell destruction and/or direct bone marrow suppression are thought possible mechanisms . Arguably the best data on hematologic adverse reactions IS MONITORING NECESSARY? to sulfasalazine come from a 1996 study involving over 10 000 patients . These patients were identiﬁed from the UK General Practice Research Database, all having IBD or rheumatoid arthritis treated with sulfasalazine.