Download Clinical Dilemmas in Inflammatory Bowel Disease by Peter Irving MD MRCP, Corey A. Siegel, David Rampton, PDF
By Peter Irving MD MRCP, Corey A. Siegel, David Rampton, Fergus Shanahan
Evidence-based information to respond to greater than 60 debatable scientific questions about inflammatory bowel diseaseClinical Dilemmas in Inflammatory Bowel ailment is a pragmatic instruction manual delivering speedy yet unique solutions to the questions and demanding situations that you're confronted with day-by-day within the medical setting.Each brief bankruptcy addresses a distinct subject and gives evidence-based suggestions on topics starting from optimising present administration via to important administration difficulties and novel remedies. This e-book is acceptable for all doctors all for the care of sufferers with IBD: verified and trainee gastroenterologists, colorectal surgeons, pathologists, radiologists, expert nurses, pharmacists, dieticians and counsellors
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10 Deltenre P, Berson A, Marcellin P, et al. Mesalazine induced chronic hepatitis. Gut 1999; 44: 886 – 8. 11 Rachmilewitz D. Coated mesalazine versus sulphasalazine in the treatment of active ulcerative colitis: a randomised trial. BMJ 1989; 298: 82– 6. 12 Lapidus A, Bangstad M, Astrom M, et al. The prevalence of gallstone disease in a defined cohort of patients with Crohn’s disease. Am J Gastroenterol 1999; 94: 1261– 6. 13 Cucion C, Sonnenberg A. The comorbid occurrence of other diagnoses in patients with ulcerative colitis and Crohn’s disease.
Prevalence of primary sclerosing cholangitis in patients with ulcerative colitis. Gastroenterology 1991; 100: 1319. 4 Ahmad J, Slivka A. Hepatobiliary disease in inflammatory bowel disease. Gastroenterol Clin North Am 2002; 31: 329– 45. 5 Terjung B, Worman HJ. Anti-neutrophil antibodies in primary sclerosing cholangitis. Best Prac Res Clin Gastroenterol 2001; 15: 629 – 42. 6 Kiyichi M, Gulten M, Gurel S, et al. Ursodeoxycholic acid and atorvastatin and the treatment of non-alcoholic steatohepatitis.
Hematologic side-effects The 5-ASAs have been associated with a wide range of hematologic side-effects in IBD. Agranulocytosis, red cell aplasia, leukopenia, thrombocytopenia and pancytopenia have all been reported. Antibody-mediated cell destruction and/or direct bone marrow suppression are thought possible mechanisms [13]. Arguably the best data on hematologic adverse reactions IS MONITORING NECESSARY? to sulfasalazine come from a 1996 study involving over 10 000 patients [14]. These patients were identified from the UK General Practice Research Database, all having IBD or rheumatoid arthritis treated with sulfasalazine.