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By J. Michael Millis, Jeffrey B. Matthews
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1016/S0140-6736(02)07451-2. 9. Guyatt GH, Oxman AD, Kunz R, Vist GE, Falck-Ytter Y, Schünemann HJ, GRADE Working Group. What is “quality of evidence” and why is it important to clinicians? BMJ (Clin Res Ed). 2008;336(7651):995–8. BE. 10. Haynes RB. Optimal search strategies for retrieving scientifically strong studies of treatment from Medline: analytical survey. BMJ (Clin Res Ed). 2005;330(7501):1179. 8F. 11. Karanicolas PJ, Davies E, Kunz R, Briel M, Koka HP, Payne DM, et al. The pylorus: take it or leave it?
This heterogeneity can be due to differences in the patient population studied, the nature of the intervention, means of measuring outcomes or other study design features. Directness This is the degree to which the studies actually address the question we are interested in. The results may be indirect because the study population is different from one we are interested in or the intervention is differs substantially from what we are interested in. This is slightly different from the above example the indirectness refers to the whole body of evidence in relation to our specific question.
4. Toro A, Mahfouz AE, Ardiri A, Malaguarnera M, Malaguarnera G, Loria F, Bertino G, Di Carlo I. What is changing in indications and treatment of hepatic hemangioma. A review. Ann Hepatol. 2014;13(4):327–39. 5. Yoon SS, Charny CK, Fong Y, Jarngin WR, Schwartz LH, Blumgart LH, DeMAtteo RP. Diagnosis, management, and outcomes of 115 patients with hepatic hemangioma. Am Coll Surg. 2003;3:392–402. 6. Schnelldorfer T, Ware AL, Smoot R, Schleck CD, Harmsen WS, Nagorney DM. Management of giant hemangioma of the liver: resection versus observation.