Download Environmental Radiation Effects on Mammals: A Dynamical by Olga A. Smirnova (auth.) PDF
By Olga A. Smirnova (auth.)
This textual content is dedicated to the theoretical reviews of radiation results on mammals. It makes use of the framework of built deterministic mathematical versions to enquire the results of either acute and persistent irradiation in a variety of doses and dose charges on very important physique platforms together with hematopoiesis, small gut and humoral immunity, in addition to at the improvement of autoimmune illnesses. therefore, those types can give a contribution to the advance of the process and quantitative methods in radiation biology and ecology. this article is additionally of sensible use. Its modeling reports of the dynamics of granulocytopoiesis and thrombocytopoiesis in people testify to the potency of employment of the built versions within the research and prediction of radiation results on those hematopoietic strains. those versions, in addition to the competently pointed out versions of different very important physique platforms, may supply a greater knowing of the radiation dangers to healthiness. The modeling predictions will let the implementation of more suitable preventive and protecting measures for individuals living in components with increased radiation history and astronauts on long term area missions. finally, the types of the radiation-induced mortality demonstrated the theoretical foundations of a brand new individual-based method of radiation probability overview. those versions hence let one to foretell the mortality dynamics and typical life-span shortening for people and populations uncovered to acute and low-level power radiation. due to its theoretical and functional advantages, this e-book is as worthy for lecturers, scientists and researchers operating within the box of mathematical modeling of organic platforms because it is for these operating within the fields of radiation biology, ecology and drugs. it truly is both valuable for Aerospace businesses and numerous organisations that take care of the issues of environmental safeguard and radiation safety.
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Extra resources for Environmental Radiation Effects on Mammals: A Dynamical Modeling Approach
Sample text
Having decreased to minimal values, the concentrations of X1 and X2 cells increase, reach a maximum, decrease, and return to their normal levels. In turn, having decreased to a minimal value, the X3 cell concentration increases and reaches the normal level practically without oscillations. The dose dependence of the minimal concentrations of X1 and X2 cells in the erythropoietic model is the same as those in the lymphopoietic and thrombocytopoietic models: The minimal level decreases as the radiation dose D increases.
As one can see, the concentration of X3 cells decreases during the first 8 days after irradiation. Then the thrombocyte concentration increases. By the 16th postirradiation day, it reaches a maximum and then decreases again. The recovery process, having the character of damped oscillations, completes within 50 days. The modeling results on the postirradiation dynamics of X3 cell concentration agree with the respective experimental data [4] on the kinetics of the thrombocyte concentration in acutely irradiated mice (see Fig.
A megakaryocyte can have 4, 8, 16, 32, or 64 nuclei. When the number of nuclei reaches 8, the megakaryocyte starts producing thrombocytes, which subsequently leave the bone marrow and pass into the blood. The number of thrombocytes produced by one megakaryocyte is proportional to the volume of its cytoplasm, which in turn is proportional to the number of nuclei of the mature megakaryocyte. On average, a megakaryocyte produces about 3000–4000 thrombocytes and then dies. Blood thrombocytes also undergo a natural process of dying.