Download Expert Opinion on Biological Therapy by EDITOR-IN-CHIEF: Michael Morse: Duke University Medical PDF
By EDITOR-IN-CHIEF: Michael Morse: Duke University Medical Centre, USA
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Extra resources for Expert Opinion on Biological Therapy
Sample text
Neither a virological breakthrough nor significant adverse events were noticed during tenofovir monotherapy. Expert Opin. Biol. Ther. (2011) 11(3) Vigano` & Lampertico A combination of emtricitabine and tenofovir from the start versus tenofovir as monotherapy has been evaluated for patients with incomplete response to adefovir dipivoxil. At week 48, 81% of patients initially given tenofovir or tenofovir/emtricitabine had HBV DNA levels below 400 copies/ml. The presence of baseline lamivudine- or adefovir dipivoxil-resistance-associated mutations did not affect response, however adherence to therapy appeared to be the primary factor associated with HBV DNA levels below 400 copies/ml at week 48 [103].
Years of post-IFN follow-up Figure 3. In HBeAg-negative chronic hepatitis B patients treated with PEG-IFN a-2a ± lamivudine for 48 weeks, the rates of HBsAg loss progressively increased up to 5 years. Adapted from [27-29]. another nucleotides analogue has been suggested. However, results with the 1-year lamivudine and telbivudine combination therapy were similar to those obtained with telbivudine alone [50]. The combination therapy with lamivudine and adefovir in comparison with lamivudine monotherapy showed lower serum HBV DNA levels and higher rates of ALT normalization, lower rates of lamivudine resistance (19 versus 44%, respectively) but similar HBeAg seroconversion [51].
2 In a 4-year study of 315 patients, 86% of HBeAg-negative patients had full suppression of HBV DNA in an intent-totreat analysis, with similar efficacy in patients who received tenofovir monotherapy for the entire study (85%) and those who started on adefovir dipivoxil and later switched to tenofovir (87%) [96]. In a per-protocol analysis, 99% of participants in the ongoing tenofovir arm and 100% in the adefovir dipivoxil-to-tenofovir arm achieved undetectable HBV viral load. 5 mg/dl increase in creatinine.