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By J. W. Hand (auth.), Professor Dr. rer. nat. Christian Streffer (eds.)
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Additional resources for Hyperthermia and the Therapy of Malignant Tumors
Example text
1982). Under the same conditions a strong decrease of liver glycogen has been observed. The hepatic glycogen value remains low during the following 24 h and only a slow rise is induced by a glucose load after the hyperthermic treatment. This latter result supports the finding of Skibba and Collins (1978) that gluconeogenesis is reduced in perfused rat liver if the temperature is raised to 42° C. Under normal conditions the lactate, which flows from peripheral tissues to the liver, can be used for glucose formation.
In this connection it is interesting that a correlation has been observed between inhibitors of poly (ADP-ribose)-synthetase and cell killing by heat in Chinese hamster cells (Nagle and Moss 1983). The observation that elevated temperatures cause chromosome aberrations in S-phase cells but not in Grphase cells (Dewey et al. 1980) may be due to the inhibition of DNA ligation. The Biological Basis for Tumour Therapy by Hyperthermia and Radiation 37 Enzymatic studies have shown that the DNA polymerase fJ, which is involved in unscheduled DNA synthesis for DNA repair, is more thermo sensitive than the DNA polymerase a (Dube et al.
IEEE Trans Biomed Eng BME-31: 106-114 Turner PF, Kumar L (1982) Computer solution for applicator heating patterns. Nat Cancer Inst Monogr 61: 521-532 Vaguine VA, Tanabe E, Giebeler RH, McEwen AH, Halin GM (1982) Microwave direct-contact applicator system for hyperthermia therapy research. Nat Cancer Inst Monogr 61: 461-464 Vaguine VA, Christensen DA, Lindley JH, Watson TE (1984) Multiple sensor optical thermometry system for application in clinical hyperthermia. IEEE Trans Biomed Eng BME-31: 168-172 Heat Delivery and Thermometry in Clinical Hyperthermia 23 van denBerg PM, de Hoop AT, Segal A, Praagman N (1983) The computational model of the electromagnetic heating of biological tissue with application to hyperthermic cancer therapy.