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By Ricardo F. Munoz Ph.D.
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2001, 19(2), 169–172. [93] J. B. Nguyen, R. , Convection-enhanced delivery of AAV-2 combined with heparin increases TK gene transfer in the rat brain, Neuroreport, 2001, 12(9), 1961–1964. [94] M. Y. Mastakov, K. , Recombinant adeno-associated virus serotypes 2- and 5-mediated gene transfer in the mammalian brain: Quantitative analysis of heparin co-infusion, Mol. , 2002, 5(4), 371–380. qxd 5/20/2006 12:25 PM Page 29 Recombinant Adeno-Associated Viral Vectors for CNS Gene Therapy 29 [95] M. Y.
1998, 152(2), 259–277. [108] A. Eslamboli, R. M. , Recombinant adeno-associated viral vector (rAAV) delivery of GDNF provides protection against 6-OHDA lesion in the common marmoset monkey (Callithrix jacchus), Exp. , 2003, 184(1), 536–548. [109] A. Eslamboli, B. , Continuous low-level glial cell line-derived neurotrophic factor delivery using recombinant adeno-associated viral vectors provides neuroprotection and induces behavioral recovery in a primate model of Parkinson’s disease, J. , 2005, 25(4), 769–777.
Research is being conducted at various institutes aiming at various aspects of genetics in collaboration with well renowned institutes like NIH, NEI, IOWA, UCL etc. Research has been especially focused on the genetic characterization of deafness, Usher syndrome, Pendred syndrome, retinitis pigmentosa, cataract, glaucoma, baldness, leber congenital amaurosis, asthma, cone-rod dystrophy, congenital microphthalmia, stuttering, thalassaemia, and mental retardation. The extensive research on these genetic diseases led to the identification of novel genes/loci responsible for these disorders.