Download Isoquinolines And Beta-Carbolines As Neurotoxins And by Elżbieta Lorenc-Koci (auth.), Lucyna Antkiewicz-Michaluk, PDF
By Elżbieta Lorenc-Koci (auth.), Lucyna Antkiewicz-Michaluk, Hans Rommelspacher (eds.)
the categorical subject, “Isoquinolines And Beta-Carbolines As Neurotoxins And Neuroprotectants – New views In Parkinson`S illness Therapy,” was once selected in gentle of amassing neurobiological proof indicating that, as well as exogenous neurotoxins (e.g., 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine [MPTP]), endogenous compounds may possibly play a big function within the commonest neurodegenerative issues (e.g., Parkinson`s disease). teams of amine comparable compounds, which seemed chemically like MPTP, have been detected in human mind and cerebrospinal fluid (CSF): ß-carbolines (BCs) and tetrahydroisoquinolines (TIQs). those are heterocyclic compounds shaped endogenously from phenylalanine/tyrosine (TIQs) and tryptophan, tryptamine, and 5-hydroxytryptamine (BCs), respectively and exert a large spectrum of psychopharmacological and behavioral results. The TIQs and BCs may perhaps bind to their very own excessive affinity websites on neuronal membranes linked to or positioned on the subject of the receptors of neurotransmitters. examine on TIQs and BCs is motivated additionally via their attainable function in pathological stipulations, specifically parkinsonism and alcoholism. lately, medical curiosity has been spurred through their function as neuroprotective, or even neurorestorative, anticonvulsant and antiaddictive, elements.
In this booklet we will summarize, for the 1st time, the implications from behavioral, neurochemical and molecular experiments, which reveal a large spectrum of TIQs and BCs results - from their quite light neurotoxic activities to the real neuroprotective and antiaddictive houses.
Additionally, the hot result of experimental reports in vivo have allowed a higher knowing and simultaneous comparability of the neurochemical and molecular mechanisms underlying the neuroprotective and neurotoxic activities of endogenous TIQs and BCs and feature pointed to the potential for their healing functions in neurodegenerative ailments akin to Parkinson's disease.
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Extra info for Isoquinolines And Beta-Carbolines As Neurotoxins And Neuroprotectants: New Vistas In Parkinson's Disease Therapy
Example text
Their exogenous administration elevates dopamine oxidation which leads to an increase in the formation of ROS in dopaminergic neurons. In consequence, these substances inhibit the mitochondrial complex I or/and II and induce cell death via apoptosis. Chronic administration of 1BnTIQ as well as salsolinol produced parkinsonian-like symptoms both in rodents and rhesus. Both acute and chronic administration of 1BnTIQ and salsolinol leads to the development of the abnormalities in the functioning of dopamine neurons.
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