Download Managing Failed Anti-Reflux Therapy by Peter J. Kahrilas, John E. Pandolfino (auth.), Mark K. PDF
By Peter J. Kahrilas, John E. Pandolfino (auth.), Mark K. Ferguson MD, M. Brian Fennerty MD (eds.)
Gastroesophageal reflux illness (GERD) impacts hundreds of thousands of individuals in western society. because the creation of laparoscopic innovations within the Nineteen Nineties, it really is now the most universal symptoms for surgical procedure.
This multiauthored textual content offers details at the pathophysiology of GERD, acceptable scientific administration, and correct symptoms for and function of surgical and endoscopic systems for GERD. hundreds of thousands of sufferers will event insufficient reduction from scientific treatment or will improve problems from their strategies or recurrent or new indicators afterwards; this article describes intimately the right kind overview and administration of such sufferers.
Beginning with an summary of the present realizing of the pathophysiology of GERD, the e-book strikes onto new information about tissue susceptibility, the position of bile and digestive enzymes, and cyclic adjustments in LES tone. the subsequent chapters are dedicated to ordinary healing ideas for GERD, together with way of life alterations, pharmacologic remedy, and surgical procedure. additionally, more moderen endoscopic remedies, comparable to Stretta, Endocinch, injection of bulking brokers, in addition to others, are defined. next chapters specialise in the motives for failure of clinical, endoscopic, and surgical cures. the rest of the textual content is a close exam of scientific, endoscopic, and surgical treatments for those therapy failures.
This textual content is key to any doctor who manages sufferers with GERD, together with internists, gastroenterologists, common surgeons, and thoracic surgeons.
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Extra info for Managing Failed Anti-Reflux Therapy
Example text
Part I. London: Longman, Ress, Orme, Brown; 1831. 19. Maisonneuve JG. Clinique Chirurgicale. Vol 2. Paris: Savy; 1863–1864:409–416. 20. Lannelongue. Observations avec quelques considerations pour servir a l’histoire de l’oesophagotomie interne. Mem Soc Chir Paris 1868;6:547–560. 21. Mackenzie M. Gastrostomy, oesophagostomy and internal oesophagotomy in the treatment of stricture of the oesophagus. Am J Med Sci 1883;85:420–438. 22. Gross SW. Gastrostomy, oesophagostomy, internal oesophagotomy, combined oesophagotomy, oesophagectomy and retrograde divulsion in the treatment of stricture of the oesophagus.
This stimulated interest in the use of prokinetic agents in the management of GERD. Several classes of drugs were assessed, including the dopamine antagonists metoclopramide and domperidone, the acetylcholine receptor agonist bethanechol, the serotonin-4 (5-HT4) receptor agonist cisapride, and the motilin agonist erythromycin. Metoclopramide was shown to be effective in reducing symptoms of acid reflux by increasing lower esophageal sphincter pressure and by decreasing gastric emptying time. 103,104 Bethanechol was demonstrated to increase resting lower esophageal sphincter pressure resulting in a decrease in acid reflux, and improve esophageal clearance.
Scolapio JS, Pasha TM, Gostout CJ, et al. A randomized prospective study comparing rigid to balloon dilators for benign esophageal strictures and rings. Gastrointest Endosc 1999;50:13–17. 33. Blandin PF. Retrecissement de l’oesophage traite par dilation temporaire. J Med Chir Pract 1847;18:72–73. 34. Hurt R. The History of Cardiothoracic Surgery from Early Times. New York: The Parthenon Publishing Group; 1996:328. 35. Symonds CJ. A case of malignant stricture of the oesophagus. Trans Clin Soc 1885;18:155–158.