Download Physiologically Based Pharmacokinetic Modeling: Science and by Micaela Reddy, R. S. Yang, Melvin E. Andersen, Harvey J. PDF
By Micaela Reddy, R. S. Yang, Melvin E. Andersen, Harvey J. Clewell III
A definitive, unmarried resource of data on PBPK modeling
Physiologically-based pharmacokinetic (PBPK) modeling is changing into more and more vital in human healthiness threat tests and in aiding pharmacodynamic modeling for poisonous responses. equipped by means of periods of compounds and modeling reasons so clients can quick entry info, this is often the 1st accomplished reference of its kind.
This booklet offers an summary of the underlying rules of PBPK version improvement. Then it offers a compendium of PBPK modeling details, together with ancient improvement, particular modeling demanding situations, and present practices for:
* Halogenated Alkanes
* Halogenated Alkenes
* Alkene and fragrant Compounds
* Reactive Vapors within the Nasal Cavity
* Alkanes, Oxyhydrocarbons, and similar Compounds
* insecticides and chronic natural Pollutants
* Dioxin and comparable Compounds
* Metals and Inorganic Compounds
* Drugs
* Antineoplastic Agents
* Perinatal Transfer
* Mixtures
* Dermal publicity Models
as well as pinpointing particular info, readers can discover various modeling ideas and purposes. An authoritative reference for toxicologists, ecotoxicologists, probability assessors, regulators, pharmacologists, pharmacists, and graduate scholars in pharmacokinetics and toxicology, Physiologically-Based Pharmacokinetic Modeling compiles details from leaders within the box and discusses destiny instructions for PBPK modeling.Content:
Chapter 1 advent: A old viewpoint of the advance and purposes of PBPK versions (pages 1–18): Melvin E. Andersen, Raymond S. H. Yang, Harvey J. Clewell and Micaela B. Reddy
Chapter 2 Halogenated Alkanes (pages 19–54): Micaela B. Reddy, Ivan D. Dobrev and James E. Dennison
Chapter three Halogenated Alkenes (pages 55–78): Dong?Soon Bae, Melvin E. Andersen and Harvey J. Clewell
Chapter four Alkene and fragrant Compounds (pages 79–117): James E. Dennison
Chapter five Reactive Vapors within the Nasal hollow space (pages 119–140): James E. Dennison and Melvin E. Andersen
Chapter 6 Alkanes, Oxyhydrocarbons and similar Compounds (pages 141–166): Robert T. Davidson and Micaela B. Reddy
Chapter 7 insecticides and chronic natural pollution (POPs) (pages 167–205): Carol J. Belfiore
Chapter eight Dioxin and comparable Compounds (pages 207–237): Yasong Lu
Chapter nine Metals and Inorganic Compounds (pages 239–270): Julie Campain
Chapter 10 medications (pages 271–296): Tami S. McMullin
Chapter eleven Antineoplastic brokers (pages 297–317): Wendy Pott O'brien
Chapter 12 Perinatal Pharmacokinetics (pages 319–347): sunlight okay. Lee
Chapter thirteen combos (pages 349–373): Raymond S. H. Yang and Melvin E. Andersen
Chapter 14 Dermal publicity versions (pages 375–387): Micaela B. Reddy
Chapter 15 Conclusions and destiny instructions (pages 389–399): Melvin E. Andersen, Micaela B. Reddy, Harvey J. Clewell and Raymond S. H. Yang
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Extra resources for Physiologically Based Pharmacokinetic Modeling: Science and Applications
Sample text
Med. 37, 42– 49. , Bush, M. , Subramaniam, R. , Black, K. , Kimbell, J. , Morgan, K. , Subramaniam, R. , Morris, J. , and Ultman, J. S. (1998). Application of a hybrid computational fluid dynamics and physiologically based inhalation model for interspecies dosimetry extrapolation of acidic vapors in the upper airways. Toxicol. Appl. Pharmacol. 152, 211–231. Gargas, M. , and Andersen, M. E. (1988). Physiologically based approaches for examining the pharmacokinetics of inhaled vapors. In: Toxicology of the Lung, D.
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