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There were 4 deaths, 14 recurrent acute MIs, 15 episodes of unstable angina, 24 episodes of recurrent angina requiring hospitalisation, 17 cases of post-angioplasty restenosis and 24 patients needed myocardial revascularisation. There were 36, 34, 18 and 16 complications in the quartiles 1, 2, 3, and 4, respectively. 07) (GISSI Prevenzione Investigators. 1999). A second study (Muntwyler, J. et al 1998) examined subjects recruited into the Physicians’ Health Study (Steering Committee of the Physicians; Health Research Group, 1989, (Steering Committee of the Physicians' Health Study Research Group.

G. 2000). Myocardial infarction: full guideline Final (May 2007) Page 60 of 231 Post MI Full Guideline – Final Version – May 2007 The fifth study was a retrospective case-control study in unselected patients who had suffered sudden cardiac arrest and had a clinical history of coronary artery disease (de Vreede Swagemakers, J. J. et al 1999). These patients were compared with a group of unselected age- and gender-matched coronary artery disease control patients (de Vreede Swagemakers, J. , Gorgels, A.

Et al 2002). The SAVE trial was a randomised double-blind placebocontrolled study designed to test the hypothesis that long-term administration of an angiotensin-converting enzyme inhibitor to MI survivors would lessen mortality and improve clinical outcomes (Moye, L. , Pfeffer, M. , and Braunwald, E. 1991) (Pfeffer, M. , Moye, L. A. et al 1992). Alcohol intake was classified as follows: non drinkers (0 drinks/week) (1276 patients), light-to-moderate drinkers (1 to 10 drinks/week) (717 patients), and heavy drinkers (>10 drinks/week) (235 patients).

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