Download Preventive Pharmacotherapy of Headache Disorders (Frontiers by Jes Olesen, Stephen D. Silberstein, Peter Tfelt-Hansen PDF
By Jes Olesen, Stephen D. Silberstein, Peter Tfelt-Hansen
Lots of the time-honored headache medications are used to prevent a headache assault that's already in growth, or approximately to start. besides the fact that, there's now a transforming into physique of analysis aimed toward constructing medicines that may be taken frequently to avoid complications from beginning. those medicines can be targetted at sufferers whose complications are common or who get their complications at predictable occasions. This publication stories the possibility of prophylactic remedy of headache. It offers many of the current facts within the box of pharmaco-prophylaxis of migraine and different persistent complications and should therefore, function a platform for brand spanking new projects within the box. The publication reports the study into the pharmacological mechanisms concerned, the periods of substances in improvement and the medical trials methodology.
The editors have accrued jointly the prime foreign specialists to supply a booklet that might entice neurologists taking good care of headache sufferers, researchers within the box and people dependent within the pharmaceutical industry.
Read or Download Preventive Pharmacotherapy of Headache Disorders (Frontiers in Headache Research) PDF
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Additional resources for Preventive Pharmacotherapy of Headache Disorders (Frontiers in Headache Research)
Example text
20 The advantages of this approach are that it can be used to compare the efficacy of different interventions measured on continuous rather than dichotomous scales, and even using different outcome measures. The z-score output is in standard deviation units, and therefore is scale-free. The (major) disadvantage of effect size is that it is not intuitive for clinicians. Number-needed-to-treat (NNT) The NNT is the number of people who have to be treated for one to achieve the specified level of benefit.
Thus if very high doses of, for example, verapamil are used with good efficacy, cluster patients are normally willing to cope with moderate or even severe adverse events. References Aube M. Migraine in pregnancy. Neurology 1999; 53 (Suppl 1): S26–8. Backonja M, Beydoun A, Edwards KR, Schwartz SL, Fonseca V, Hes M, LaMoreaux L, Garafola E. Gabapentin for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus: a randomized controlled trial. JAMA 1998; 280: 1831–6. Begg C, Cho M, Eastwood S, Horton R, Moher D, Olkin I, Pitkin R, Rennie D, Schulz KF, Simel D, Stroup DF.
Major harm may be defined in a set of RCTs as intervention-related study withdrawal, and be calculated from those numbers. Precise estimates of major harm will require much wider literature searches to trawl for case reports or series. Minor harm may similarly be defined in a set of RCTs as reported adverse effects. The utility of these reports is because they are reported simply as present or absent, with no indication of severity or importance to the patient. Conclusion: using NNT and NNH to evaluate analgesics In the ideal world you will have three numbers for each intervention, an NNT for benefit and NNHs for minor and major harm.