Download Thrombolytic Therapy in Acute Ischemic Stroke II by L. R. Caplan, M. Gent (auth.), Gregory J. del Zoppo M.D., PDF

By L. R. Caplan, M. Gent (auth.), Gregory J. del Zoppo M.D., Etsuro Mori M.D., Prof. Dr. Werner Hacke (eds.)

Over the decade, curiosity in therapy of ischemic stroke has elevated considerably. possibly the only most vital characteristic of makes an attempt to enhance the result of stroke sufferers has been that the interventions be utilized in the very early hours of stroke signs. This has spawned efforts to appreciate the vascular and neuronal responses to cerebral artery reperfusion experimentally. very important potential medical reviews of thrombolysis in acute ischemic stroke were accomplished, and big placebo-controlled, symptom-based stories at the moment are underway world wide. the following, we think of the valuable good points of these reviews, their experimental foundation, and the longer term significance of adjunctive treatments to recanalization in focal mind ischemia acutely. dangers and merits are mentioned. This assortment advantages from the reviews of specialists and staff during this speedily evolving and intriguing field.

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Additional info for Thrombolytic Therapy in Acute Ischemic Stroke II

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In human pathological material, McCormick and Schochet describe "cracking:' an artifact occurring within 36 - 48 h of onset, as a curvilear plane of cleavage, separating necrotic tissue from relatively intact adjacent tissue [19]. Their Figure 164 shows a "crack" contiguous with a blood clot penetrating the lateral ventricle in the proximal distribution of a very bloody hemorrhagic infarct from a marantic embolism. Dissection of clotted blood along a similar path from a deep homogeneous blood clot to the ipsilateral ventricle was a common observation in some of our early unpublished dog specimens, and in the Laurent primate series [18].

Several thrombolytic agents administered in a variety of doses [3 - 6, 11-13] were shown to accomplish partial or complete arterial recanalization in the setting of acute cerebral embolism or thrombosis. In the mid- and late 1980s, symptom-based delivery of thrombolytic therapy for acute ischemic stroke emerged as a complementary strategy. It was hoped that delivery of agents very early after the onset of symptoms [1], prior to the performance of cerebral arteriography, could offset the disadvantages of treatment without knowledge of arterial anatomy.

In: Adams HJ, Corsellis JAN, Duchen LW (eds) Greenfield's neuropathology. John Wiley and Sons, New York, p 125 29. Yashida Y, Dereski MO, Garcia JH, Hetzel FW, Chopp M (1992) Photoactivated photofrin II: Astrocytic swelling precedes endothelial injury in rat brain. 111 Clinical Dials of Fibrinolytic Agents in Carotid Territory Cerebml Ischemia Symptom-Based Trials of Intravenous rt-PA in Acute Stroke * T. Brott As thrombolytic therapy developed as a potential intervention for acute ischemic stroke during the 1980s, early clinical investigation depended upon pretreatment cerebral arteriography [5].

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