Download Viral Vectors for Gene Therapy: Methods and Protocols by Edward A. Burton, Shaohua Huang, William F. Goins (auth.), PDF

By Edward A. Burton, Shaohua Huang, William F. Goins (auth.), Curtis A. Machida (eds.)

The promise of gene treatment should be discovered provided that achievable vectors are available to bring healing genes. In Viral Vectors for Gene treatment: tools and Protocols, major researchers from academia and biotechnology describe confirmed molecular tools for the development, improvement, and use of virus vectors for gene move and gene remedy. delivering specified step by step directions to make sure profitable effects, those specialists aspect using herpes viruses, adenoviruses, adeno-associated viruses, uncomplicated and complicated retroviruses, together with lentiviruses, and different virus structures for vector improvement and gene move. extra chapters exhibit using virus vectors within the mind and significant fearful method. every one protocol features a dialogue of the foundations concerned, quite a few charts and tables, abundant references, and notes on attainable difficulties, troubleshooting, and substitute tactics.
entire and hugely useful, Viral Vectors for Gene remedy: tools and Protocols presents not just researchers with the fundamental instruments had to layout precise gene supply vectors, but additionally clinicians with an figuring out of the way to use viral vectors to the therapy of genetic disorders.

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2000) Effective treatment of experimental glioblastoma by HSV vector-mediated TNFalpha and HSV-tk gene transfer in combination with radiosurgery and ganciclovir administration. Mol. Ther. 2, 114–120. 139. , Contreras, J. , Jiang, X. , et al. (2000) Genetically modified CD34+ cells as cellular vehicles for gene delivery into areas of angiogenesis in a rhesus model. Gene Ther. 7, 43–52. 140. , Anderson, D. , Stolz, D. , and Glorioso, J. C. (1998) Recombinant herpes simplex virus type 1 engineered for targeted binding to erythropoietin receptor-bearing cells.

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