By Daniel J. Klionsky
Klionsky (life sciences, U. of Michigan, Ann Arbor) defines "autophagy" as "a approach within which the telephone mostly undergoes membrane rearrangement to sequester a component to cytoplasm, bring it to a degradative organelle and recycle the macromolecular materials. He argues that, within the conventional view of organelles as mobile rubbish disposals, the continued force towards homeostatis among mobile loss of life and synthesis has been missed. His creation additionally lists the hot nomenclature for 27 autophagy-related genes. In 22 different chapters, foreign members evaluation autophagy in organisms from yeast to people and its roles in metabolism, getting older, melanoma and neuromuscular illnesses. a few pictures are in colour.
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Extra resources for Autophagy
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23. Yokota S, Himeno M, Kato K. Degradation of excess peroxisomes by cellular autophagy: Immunocytochemical and biochemical analysis. Acta Histochem Cytochem 1994; 27:573-579. 24. Reunanen H, Punnonen E-L, Hirsimäki P. Studies on vinblastine-induced autophagocytosis in mouse liver. V. A cytochemical study on the origin of membranes. Histochemistry 1985; 83:513-517. 25. Yamamoto A, Masaki R, Fukui Y et al. Absence of cytochrome P-450 and presence of autolysosomal membrane antigens on the isolation membranes and autophagosomal membranes in rat hepatocytes.
Pfeifer U. Inhibition by insulin of the formation of autophagic vacuoles in rat liver. A morphometric approach to the kinetics of intracellular degradation by autophagy. J Cell Biol 1978; 78:152-167. 45. Mizushima N, Yamamoto A, Hatano M et al. Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells. J Cell Biol 2001; 152:657-667. 46. Kabeya Y, Mizushima N, Ueno T et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.