By Keith D. Lindor, Jayant A. Talwalkar
Over the last 20 years, there was a gentle elevate in wisdom linked to the medical manifestations of cholestatic liver affliction. according to those medical events, this e-book presents worthy and well timed details at the ever-expanding topic of cholestatic liver illness. It provides clinical updates from major specialists which relate to the medical overview and administration of cholestatic liver issues.
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Additional info for Cholestatic Liver Disease (Clinical Gastroenterology)
Patients with this disorder usually present with a prodrome of fatigue, anorexia, and nausea. Right-sided abdominal pain and jaundice typically follow. Laboratory abnormalities include elevated aminotransaminases (2- 8 times the upper limit of normal), elevated alkaline phosphatase (>3 times the upper limit of normal) and hyperbilirubinemia (25). Because of this nonspecific presentation, patients with drug-induced cholestatic hepatitis may be misdiagnosed with acute cholecystitis or acute cholangitis (13).
Hepatolithiasis (intrahepatic stone) during octreotide therapy for acromegaly: a case report. Pituitary 2000; 3: 227- 2 30. 41. Zinberg J, Chernaik R, Coman E, Rosenblatt R, and Brandt U . Reversible symptomatic biliary obstruction associated with ceftriaxone pseudolithiasis. Am J Gastroenterol 1991; 86: 1251- 1 254 . 42. Sautereau D, Moesch C, Letard JC, Cessot ,F Gainant A, and Pillegand B. Recurrence of biliary drug lithiasis due to dipyridamole. Endoscopy 1997; 29: 4 2 1- 4 2 3. 43. K r eek MJ.
In a randomized, double-blind, placebo-controlled trial, intravenous naloxone, an opioid antagonist, was given to patients with pruritus. The treatment group showed a significant reduction in scratching and had a reduction in the perception of pruritus (85). In a pilot study of 16 patients, naltrexone, an oral opioid antagonist, was also effective at improving sleep, pruritus, and fatigue (86). These beneficial effects of naltrexone were tempered by opiate withdrawal side effects occurring in 50% of treated patients.