By Marco Del Chiaro, Stephan L. Haas, Richard D. Schulick
This booklet offers an in depth, up to date evaluation of cystic tumors of the pancreas, with insurance of all points of analysis and therapy (medical, endoscopic, and surgical). After establishing chapters on pathology and type, cytology, molecular biology, and epidemiology, the function of every of the appropriate diagnostic tools is thoroughly tested. The treatment-related chapters describe surgical techniques, together with minimally invasive surgical procedure, in addition to ablation modalities and chemo-radiotherapy. Thorough suggestions can be supplied particularly at the administration of cystic tumors in high-risk instances and on follow-up. The authors are international opinion leaders of their box who've contributed state of the art chapters, with emphasis on transparent diagnostic and healing algorithms and with quite a few aiding tables and illustrations.
Owing to the common use of imaging modalities, clinicians are being faced by way of more and more sufferers with cystic tumors of the pancreas, starting from benign cysts to metastasized malignancies. The widening spectrum of accessible diagnostic measures has ended in controversy over the alternative of extra technique of research while cystic alterations are encountered, and the expansion in healing strategies has equally been followed via massive debate over their use. by contrast history, Cystic Tumors of the Pancreas should be a priceless resource of suitable details for either clinicians and surgeons and also will be of curiosity to radiologists, pathologists, and easy scientists.
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Extra resources for Cystic Tumors of the Pancreas: Diagnosis and Treatment
Cancer Cytopathol. 2014;122(1):40–7. 23. Pitman MB, et al. Standardized terminology and nomenclature for pancreatobiliary cytology: the Papanicolaou Society of Cytopathology guidelines. Diagn Cytopathol. 2014;42(4):338–50. 24. Belsley NA, et al. Serous cystadenoma of the pancreas: limitations and pitfalls of endoscopic ultrasoundguided fine-needle aspiration biopsy. Cancer. 2008; 114(2):102–10. 25. Lal A, et al. Microcystic adenoma of the pancreas: clinical, radiologic, and cytologic features. Cancer.
Gastrointest Endosc. 2013;77(4):669–70. 5. Wu J, Jiao Y, Dal Molin M, et al. Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways. Proc Natl Acad Sci U S A. 2011;108(52):21188–93. 6. Wu J, Matthaei H, Maitra A, et al. Recurrent GNAS mutations define an unexpected pathway for pancreatic cyst development. Sci Transl Med. 2011;3(92): 92ra66. 7. Bosman F, Carneiro F, Hruban RH, Theise N (eds). WHO classification of tumours of the digestive system.
The most important distinction is between low-grade cells and high-grade cells since it is the high-grade cells that will represent a high-risk feature for malignancy. MCN are lined by mucinous epithelial cells similar to gastric-type epithelial cells. The progression from low-grade to high-grade cyst-lining cells of an MCN is similar to that of the low-grade dysplastic gastric-type cyst-lining cells of IPMN. Cytological features associated with various grades of dysplasia (low, intermediate, and high) have been described for IPMN [22, 31–35].