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By David W. Day, Jeremy R. Jass, Ashley B. Price, Neal A. Shepherd, James M. Sloan, Nicholas J. Talbot, Geraint T. Williams, Bryan F. Warren

Morson and Dawson's Gastrointestinal Pathology is among the 'Gold criteria' of pathology textbooks. it's been thoroughly revised to include the most recent advances during this swiftly evolving box together with the advancements in gastric melanoma and Helicobacter pylori and the revised category of alternative universal gastrointestinal stipulations. This re-creation incorporates a wealth of latest fabric offered in complete color for the 1st time.

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Extra resources for Morson and Dawson's Gastrointestinal Pathology

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A morphologic study of forty-two resected specimens. Am J Surg Pathol, 1994; 18: 327. 56 Goldblum JR, Rice TW, Richter JE. Histopathologic features in esophagomyotomy specimens from patients with achalasia. Gastroenterology, 1996; 111: 648. 57 Bosher P, Shaw A. Achalasia in siblings. Clinical and genetic aspects. Am J Dis Child, 1981; 135: 709. 58 Wong RKH, Maydonovitch CL, Metz SJ, Baker JR. Significant DQw1 association in achalasia. Dig Dis Sci, 1989; 34: 349. 59 Verne GN, Hahn HB, Pineau BC, Hoffman BJ, Wojciechowski BW, Wu WC.

Other organs such as the small bowel, colon and spleen may also enter the hernia sac. Compared to sliding types of hernia, reflux oesophagitis is uncommon in the pure type of paraoesophageal hernia, but bleeding from erosions or ulcer may occur and ulcers may perforate with mediastinal inflammation and abscess [46]. With giant hernias, obstruction, incarceration and strangulation may result [47–49]. Increase in intra-abdominal pressure, as with sliding hernias, is thought to be important in pathogenesis and some have occurred following previous surgery in the region of the diaphragmatic hiatus.

As separation proceeds the oesophagus elongates, mainly due to a rapid increase in growth at its cranial end rather than a primary caudal positioning of the stomach. Separation is complete at 35–40 days, by which time the stomach has been carried down below the developing diaphragm. Interesting anatomical studies [5] suggest that the tracheo-oesophageal septum may in fact be the primitive floor of the respiratory outgrowth. The epithelial lining is initially stratified columnar; ciliated cells develop in it by the 70-mm stage [7–9].

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