Download Neuroendocrine Tumours: Diagnosis and Management by Suayib Yalcin, Kjell Öberg PDF
By Suayib Yalcin, Kjell Öberg
This e-book is a well timed textbook that covers all elements of neuroendocrine tumors (NET) from epidemiology, pathological category and assessment and molecular biology via to diagnostic imaging tools and healing suggestions, together with the newest unique remedies. a few of the varieties of web are separately mentioned, together with carcinoid tumors, insulinomas, gastrinomas, glucagonomas, VIPomas, somatostatinomas, PPomas, medullary thyroid carcinomas, adrenocortical melanoma, pheochromocytomas, paragangliomas and non-functioning pancreatic NETs. The contributing authors are across the world well-known specialists who deliver a wealth of expertise to the topic. This ebook might be a useful resource of knowledge for practising scientific oncologists, surgeons, endocrinologists, gastroenterologists and pathologists and likewise trainees.
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Sample text
Concomitantly, another group identified p27 (CDKN1B) as a putative tumor suppressor in small intestinal NETs [46]. CDKN1B encodes a cyclin-dependent kinase inhibitor p27Kip1, which is a master regulator of the cell cycle and frequently inactivated in many forms of cancer. Importantly this gene is inactivated in MEN1 patients testing negative for MEN1 mutations [47]. While these mutations may be present in a subset of carcinoid patients, they do not account for the vast majority of the neoplastic lesions [45, 46].
Genes Chromosomes Cancer 32:177–181 19. Gortz B, Roth J, Krahenmann A, de Krijger RR, Muletta-Feurer S et al (1999) Mutations and allelic deletions of the MEN1 gene are associated with a subset of sporadic endocrine pancreatic and neuroendocrine tumors and not restricted to foregut neoplasms. Am J Pathol 154:429–436 20. Debelenko LV, Emmert-Buck MR, Zhuang Z, Epshteyn E, Moskaluk CA et al (1997) The multiple endocrine neoplasia type I gene locus is involved in the pathogenesis of type II gastric carcinoids.
In addition to pNETs, the genomic landscape of small intestinal NETs (SI NET) has recently been investigated [45, 46]. The group led by Matthew Ames [45] performed an integrative analysis of somatic mutations and copy number variations of 48 small intestine NETs. They reported genetic alterations of different members of the PI3K/Akt/mTOR pathway in 30 % of the samples and the loss of SMAD genes in 45 % of samples. Overall, the average per case mutation rate in this study was significantly lower than that of typical carcinomas but comparable to that reported for pNETs [17].