Download Nuclear Hepatology: A Textbook of Hepatobiliary Diseases by Gerbail T. Krishnamurthy PDF
By Gerbail T. Krishnamurthy
This moment version of Nuclear Hepatology: A Textbook of Hepatobiliary ailments has been revised which will surround the entire latest advancements within the box. the result's a accomplished, up to date publication that would function a prepared reference and a scientific and procedural advisor. The authors, either one of whom are nuclear medication physicians, current nuclear hepatobiliary imaging innovations within the context of the numerous different attainable diagnostic reports, thereby acquainting the reader with the function of those systems. all through, care is taken to take care of a transparent medical concentration and to stress the significance of integrating info on morphology and quantitative body structure because the foundation for analysis. all the chapters is easily illustrated and referenced. This e-book will end up worthwhile not just to nuclear drugs physicians but in addition to practitioners of radiology, inner drugs, pediatrics, gastroenterology, hepatology, fundamental care, normal surgical procedure, and liver transplantation surgical procedure.
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Additional resources for Nuclear Hepatology: A Textbook of Hepatobiliary Diseases
Example text
Four organic anion transporter proteins (OATPs) and organic anion transporter-2 (OAT2) and organic cation transporter proteins (OCT1) control uptake of anions and cations along the basolateral border (red). Sodium-dependent bile salt uptake occurs via sodium taurocholate protein (NTCP). Five multidrug resistance-associated proteins (MRPs) control secretion (reflux) from the hepatocyte back into space of Disse (blue). After intracellular transit, solute secretion into bile takes place along the canalicular domain through MRP2, multidrugresistant-1 p-glycoprotein (MDR1 and MDR3), bile salt export pump (BSEP), breast cancerresistance protein (BCRP), and flippases (ABCG5/ABCG8).
Leemans R, Manson W, Snijder JAM, Smit JW, Klasen HJ, The TH, Timens W. Immune response capacity after human splenic autotransplantation. Restoration of response to individual pneumococcal vaccine subtypes. Ann Surg 1999;229:279–285 Imaging Agents 3 Historical evolution The introduction of radiocolloids in the 1940s, whose rate of clearance from the circulation was used as an indicator of liver function, gave birth to nuclear hepatology [1]. Imaging of the liver morphology began in 1954 with gold-198 colloid using an automated rectilinear scanner developed by Cassen [2, 3].
Cholangiocytes absorb bile salts through apical sodium-dependent bile salt transporter (ASBT) and OATP1A2. After their uptake, bile salts are excreted through the basolateral membrane (via MRP3) into the peribiliary plexus where they reach the portal circulation. Bile acids and sterols also use organic solute transporters (OSTa/OSTb) to be secreted into the peribiliary plexus through the basolateral domain. Unlike the basolateral border of the hepatocyte, which lacks MRP2, the basolateral border of the cholangiocyte contains MRP2 that controls excretion of organic anions into peribiliary plexus (Fig.