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By Walter Lovenberg and Yukio Yamori (Eds.)

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33. 34. 35. 36. 37. 38. 39. 40. 41. 42. 51 p. 281. Schattauer Verlag, Stuttgart/New York, 1982. , Circulation 68 (suppl. Ill):384 (1983). , in "Hypertension" (J. Genest, 0. Kuchel, P. Hamet, and M. Cantin, e d s . ) , p . 556. McGraw-Hill, Montreal, 1983. , Life Sci. 19:935 (1976). , Am. J. Physiol. C232:165 (1977). , Horie, R . , Clin. Exp. Pharmacol. Physiol. ): 199 (1976). , Acta. Pathol. Jpn. 32 (suppl. 2):359 (1982). , Horie, R . , in "Prophylactic Approach to Hypertensive Diseases" (Y. Yamori, W.

In addition to these models, 3 further strains of interest in relation to hypertensive vascu lar diseases have been developed (FIGURE 1 ) : (i)rats with spontaneous thrombogenesis (spontaneous thrombogenic rats, STR). These die mainly of cerebral thrombosis (19); (ii)arte riolipidosis-prone rats (ALR) which develop wide-spread (Cerebral thrombosis) FIGURE 1. (Myocardial infarction) Various rat models for cardiovascular developed from SHR. diseases NUTRITIONAL CAUSATION A N D PREVENTION—EXPERIMENTAL EVIDENCE 39 arterial fat deposits when fed lipid-rich diets (20); (iii) myocardial ischemic rats (MIR) with a high prevalence of ischemic heart disease which occurs spontaneously but which is made worse by a high cholesterol diet ( 2 1 ) .

Murata in Gunma University. REFERENCES 1. , Suzuki, K. , Virchows Arch. Abt. A Path. Anat. 361: 31 ( 1 9 7 3 ) . 2 . , Mihara, T. , in "Prophylactic Approach to Hypertensive Diseases" (Y. Yamori, W . D. Freis, e d s . ) , p . 2 0 7 . Raven Press, New York, 1979. 3. , Takayama, Y. , Blood Vessels 1 5 : 148 ( 1 9 7 8 ) . 4. , Yoshida, Y. , Virchows Arch. Abt. A Path. Anat. Histol 369: 181 ( 1 9 7 6 ) . 5. , Suzuki, K. , Thrombosis R e s . (Suppl. 2) 8: 357 ( 1 9 7 6 ) . 6. , Mori, I. , Nippon Rinsho 38: 3156 (1980) (in J a p a n e s e ) .

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