Download The Human Race to the Future: What Could Happen - and What by Daniel Berleant PDF

By Daniel Berleant

Do you ask yourself in regards to the future... what issues should be like a few day, how lengthy it may possibly take, and what we will be able to do approximately it?

Substantive but imaginitive, readable, sometimes funny, and technological know-how orientated, this publication proposes attainable destiny eventualities spanning from the present century to just about eternity. such a lot chapters supply a concluding part with suggestions and infrequently, agree or disagree, the author's sometimes inimitable evaluations. many of the urged activities should be performed through members, others by way of international locations or different teams, and nonetheless others by means of the full global. Over three hundred references.

Discover "What it signifies that an Hour’s paintings Yields a Week’s Food" (chapter 1). Foresee the "Teeming towns of Mars" (chap. 21). study why it’s "Keyboards the day before today, brain examining Tomorrow" (chap. 3). have you questioned — "Will man made Intelligence Threaten Civilization?" (See chap. 12.) discover what occurs "When Genomes Get Cheap" (chap. 6). organize for an "Asteroid Apocalypse" (chap. 25). discover why you are going to reap the benefits of "Wiki-Wiki-Wikipedia" (chap. 4). How we'll "Live wherever, paintings wherever Else" (chap. 2). become aware of how the long run "Tastes just like the Singularity" (chap. 15). Get smarter with "Smart Pills’n Such" (chap. 5). adventure a "Soylent Spring" (chap. 9). comprehend nukes higher via "Deconstructing Nonproliferation" (chap. 13). prepare for a "Space Empire" (chap. 14). what's "Sic Transit Humanitas: The Transcent of Man" (chap. 26)? There’s worldwide warming, and there’s "Warm, Poison Planet" (chap. 17). yet let’s no longer ignore "Big Ice" (chap. 22). issues might relatively develop on timber with "New Plant Paradigms" (chap. 24). all of us have "Questions" (chap. 31). and lots more and plenty more!

This booklet is geared toward the reader who's drawn to the long run, and intrigued by means of technological know-how and expertise.

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Hum Gene Ther. 2006;17:291–302. 32. Klein RL, Dayton RD, Tatom JB, Henderson KM, Henning PP. AAV8, 9, Rh10, Rh43 vector gene transfer in the rat brain: effects of serotype, promoter and purification method. Mol Ther. 2008;16:89–96. 33. Burger C, Gorbatyuk OS, Velardo MJ, Peden CS, Williams P, Zolotukhin S, Reier PJ, Mandel RJ, Muzyczka N. Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous system.

Production and characterization of adeno-associated viral vectors. Nat Protoc. 2006;1:1412–28. 20. Grieger JC, Samulski RJ. Adeno-associated virus vectorology, manufacturing, and clinical applications. Methods Enzymol. 2012;507:229–54. 21. Martino AT, Herzog RW, Anegon I, Adjali O. Measuring immune responses to recombinant AAV gene transfer. Methods Mol Biol. 2011;807:259–72. 22. Duan D, Sharma P, Yang J, Yue Y, Dudus L, Zhang Y, Fisher KJ, Engelhardt JF. Circular intermediates of recombinant adeno-associated virus have defined structural characteristics responsible for long-term episomal persistence in muscle tissue.

Another comprehensive study was recently conducted by the same research group utilizing administration of the aforementioned AAV5 vectors. This study surprisingly reported the inability of their previous strategy of vector administration used in the PD rat model to directly translate therapeutic benefit in higher order mammals. In NHPs, such AAV5 administration led to increase in the GCH1 levels but not TH levels. It was speculated that other important parameters like promoter/enhancer elements were to be optimized so as to dissect the molecular basis of the incoherence seen between gene therapy of rats and monkeys [86].

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