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By Brian I. Carr

​Understanding Liver melanoma is a concise and updated assessment, which discusses prognosis, administration, sufferer care, present and rising cures, and priceless assets that clinicians promises to their sufferers. Busy healthcare execs who desire a speedy evaluate of liver melanoma in addition to a precis of present treatments will take advantage of this succinct text.

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Extra resources for Understanding Liver Cancer: A Tale of Two Diseases

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The remarkable thing is that this approach represents a paradigm shift away from (largely nonspecific) cell poisons or cytotoxins (chemotherapy), but instead to agents that work by modifying tumor cell behavior in various ways, either by directly inhibiting crucial steps in the cell growth pathway(s) or by antagonizing steps in supportive activities, such as angiogenesis, cell differentiation, cell adhesion, migration (metastasis) or immune modulation. Furthermore, because the major mechanisms by which this new set of agents (drugs and antibodies) work is often understood, for the first time in cancer therapy, predictive chemical or molecular tests can be developed to determine which patient’s cancer cells have the necessary biochemical configuration or gene expression profile to be able to respond to these new therapies (ie, personalized medicine).

Assessment of tumor extent for treatment planning: staging classifications Functional hepatic reserve, Child-Pugh classification As previously discussed, patients are grouped by definition into three categories of liver damage severity (A, B, or C), according to the Child-Pugh (CP) classification cirrhosis score (see Table 3). A patient classified as CP A has essentially normal liver function and can receive almost any therapy without extra risk resulting from their liver disease. They typically have a 100% 12-month survival, without HCC or any treatment.

2008;190:W28‑W34. 2 Park JW, Amarapurkar D, Chao Y, et al. Consensus recommendations and review by an International Expert Panel on Interventionsin Hepatocellular Carcinoma (EPOIHCC). Liver Int. 2013;33:327-337. 30 • Understanding Liver Cancer 3 Arii S, Sata M, Sakamoto M, et al. Management of hepatocellular carcinoma: Report of Consensus Meeting in the 45th Annual Meeting of the Japan Society of Hepatology (2009). Hepatol Res. 2010;40:667-685. 4 Poon D, Anderson BO, Chen LT, et al; Asian Oncology Summit.

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