Download Downstream Processing by J.A. Wesselingh, J. Krijgsman PDF
By J.A. Wesselingh, J. Krijgsman
Isolating and purifying the specified product is a vital a part of any bio-project. This processing ‘downstream’ from the fermenter is either tricky and costly. This e-book introduces all of the universal ideas, beginning within the lab and finishing within the plant. now we have written it for undergraduates in technique engineering (biotechnological, mechanical or chemical) and graduate microbiologists doing a minor at the expertise that's required to scale up their experiments to a advertisement scale
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Extra info for Downstream Processing
Sample text
Earlier descriptions of floc break-up assumed a behaviour approaching that of a liquid droplet in a shear field, where the floc is subject to fluctuating pressure causing bulgy deformation and ultimately disruption 94). The force required for disruption is a strong function of the plastic or yield stress of the floc suspension 95). However an alternative mechanism is often proposed to allow for the filamentous structure of the floc, where turbulent drag on the floc causes surface erosion 76). Complex theories for the various mechanisms, particle dimensions and scales of turbulence have been presented by Parker et al.
Lo- . . . . __ --. 9. Fig. 14. Effect of rate of shear on is9 soya protein precipitate particle size 89) Time of shearing, 300 s ( 9 1800 s ( o ) . Ranges of dg0 values for times of shearing from 300 s to 7200 s are shown. 5 % weight; temperature, 23 ~ 001 ................. n i , i i . . 104 105 the rate of orthokinetic aggregation during which large precipitate particles mop up the fines. A most important factor determining protein precipitate aggregate strength is the history of preparation.
Most existing centrifuges display this problem and without expensive modifications the only alternative is to contain the equipment in some form of cabinet as discussed by Wang et al. 144). The solid phase may also create biosafety problems, particularly for batch machines where the solids are handled by process operators. Equally the use of sealed systems and protective clothing can result in considerable operational difficulties. The processing of systems with organic solvents can create explosive hazards and inert gas blanketing may be required 145) Another safety aspect often overlooked is the corrosive nature of precipitants such as ammonium sulphate.