Download Optical Coherence Tomography: Technology and Applications 3 by Wolfgang Drexler, James G. Fujimoto PDF
By Wolfgang Drexler, James G. Fujimoto
Optical coherence tomography (OCT) is the optical analog of ultrasound imaging and is a robust imaging process that allows non-invasive, in vivo, excessive solution, cross-sectional imaging in organic tissue. Between 30 to forty Million OCT imaging strategies are played in line with yr in ophthalmology. The total industry is expected at greater than 1/2 Billion USD.
A new new release OCT technology was built, dramatically expanding solution and pace, attaining in vivo optical biopsy, i.e. the visualization of tissue architectural morphology in situ and in actual time. practical extensions of OCT expertise allow non-invasive, intensity resolved sensible review and imaging of tissue.
The ebook introduces OCT know-how and functions not just from an optical and technological perspective, but in addition from the biomedical and scientific perspective. This moment version is generally prolonged and covers significantly more topics then the 1st version of this booklet. The chapters are written by leading overseas learn teams, in a method understandable to a huge viewers. it will likely be of curiosity not just to physicists, scientists and engineers, but in addition to biomedical and scientific researchers from diverse clinical specialties
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The reference pulse is generated by the same laser source and is delayed by a variable time delay DT using a mechanical optical delay line. The nonlinear mixing process creates an ultrahigh-speed optical gate. If IS(t) is the signal that is being detected and Ir(t) is the reference pulse used as the gate, the response function S(DT) is SðDT Þ $ ð1 À1 I s ðtÞ I r ðt À DT Þ dt 1 Introduction to OCT 9 Fig. 4 Early demonstration of femtosecond optical ranging in biological systems. (left) Femtosecond echoes of backscattered light (signal) are detected using nonlinear second harmonic generation, mixing the signal with a delayed reference pulse.
7 OCT image of human artery ex vivo and corresponding histology. The OCT image shows fibrocalcific plaque (right three-quarters of specimen) and fibroatheromatous plaque (left). The fatty-calcified plaque scatters light and attenuates the OCT beam, limiting the image penetration depth (From Huang et al. [1]) Optical coherence tomography has the advantage that it can be implemented using fiber-optic components and integrated with a wide range of medical instruments. OCT systems can be divided into an imaging engine (consisting of an interferometer, light source, and detector) and imaging devices or probes.
Early studies were performed ex vivo to correlate OCT images with histology for gastrointestinal [40, 41, 44, 50], biliary [45], female reproductive [47, 49], pulmonary [46], and urinary [42, 48] pathologies. 12 shows an example from an early OCT imaging study of gastrointestinal neoplasia. The figure shows OCT images and corresponding histology of normal colon and adenocarcinoma ex vivo. Imaging was performed with an axial resolution of $15 mm in tissue at 1,300 nm wavelength. The OCT image of normal colon shows normal glandular organization associated with columnar epithelial structure.